Project 3

Adhesion of Tumor Cells in the Vascular Microenvironment


This project is focused on understanding the fundamental physical mechanisms of circulating tumor cell (CTC) adhesion to inflamed endothelium under flow, as a critical step in the hematologic spread of metastatic cancers. This complex problem is inherently multidisciplinary, and necessitates a team of investigators with expertise in fluid physics across multiple length and time scales, as well as a quantitative understanding of chemical reaction kinetics that are strongly coupled to externally applied force. At Cornell University microscale fluid mechanics and advanced optical microscopy have been applied to develop powerful enabling technologies for the study of the molecular and cellular basis of metastatic cancer, while at Weill Medical College and SUNY Buffalo the biological components and their behavior can be studied in detail in the context of animal studies or clinical phenotypes.